A SECRET WEAPON FOR NAD+ AND ITS EFFECT ON DNA REPAIR

Following, we addressed cells with different concentrations of NAD+. When included for 24 h at eighty µM in HeLa and four hundred µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Prolonged Information Fig. 1k,l). Additionally, sixteen µM of NAD+ was sufficient to scale back fork velocity by ~forty% in HeLa cells with